An in vivo study in mice showing that Honokiol can protect the heart from hypertrophy. Hyperthrophy is a thickening of cardiac muscle often caused by chronic high blood pressure that can lead to heart failure. When injected into mice Honokiol reduced the excess growth of individual cardiac muscle cells, decreased ventricular wall thickness and prevented the accumulation of interstitial fibrosis—a stiffening of cardiac muscle cells that reduces their ability to contract. It also protected heart muscle cells from the damage caused by oxidative stress, which can damage DNA.
Apparently the mechanism is that Honokiol activates SIRT3. It is rare that compounds are found to be pharmacologic activators of SIRT3. The SIRT3 activation effectively blocked both the induction and progression of cardiac hypertrophy in mice.
The researchers have not yet tested whether Honokiol taken by mouth has the same effect but are planning to do so.
“To the best of our knowledge, this is the first report to describe “Until now, caloric restriction combined with endurance exercise has been the only way to boost SIRT3 levels. Very few people have been able to follow such a rigorous regimen.”