In vitro study shows that Honokiol suppresses metastasis of aggressive renal cell cancer

Renal cell cancer (also called kidney cancer or renal adenocarcinoma) is a disease in which malignant (cancer) cells are found in the lining of tubules (very small tubes) in the kidney. There are 2 kidneys, one on each side of the backbone, above the waist. The tiny tubules in the kidneys filter and clean the blood. They take out waste products and make urine.

The preclinical in vitro study on honokiol and renal cancer cell metastasis, “Honokiol suppresses metastasis of renal cell carcinoma by targeting KISS1/KISS1R signaling,” was conducted at the Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, IN. Results from this study, published in the International Journal of Oncology, showed honokiol suppressed metastasis in aggressive renal cell carcinoma (RCC), in a dose-dependent manner. Specifically, researchers found that honokiol markedly upregulated the metastasis-suppressor gene (KISS1) and its receptor (KISS1R), in the highly metastatic renal cancer cell line, 786-0. This is critical, since 25-30% of patients with RCC have metastatic spread by the time they are diagnosed, with 5-year survival rates <10%.

“Previous studies have confirmed honokiol targets multiple signaling pathways involved in cancer proliferation: NF-kB, STAT3, mTOR, EGFR and others. This new study demonstrating honokiol’s ability to upregulate the metastasis-suppressor gene KISS1 in aggressive renal cancer cell lines, adds to our understanding of the diverse protective actions that honokiol performs at the cellular and genetic levels,” states Dr. Isaac Eliaz, MD, MS, LAc, (Amitabha Medical Clinic, Santa Rosa, CA), one of the lead investigators involved in this study. “Given honokiol’s diverse mechanisms against cancer, including synergy with certain chemotherapy drugs and inhibition of multi-drug resistance, progression to clinical trials is urgently needed to explore this unique compound as a viable adjunct treatment against multiple types of cancer.”

You can find the study here.

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