Sirtuins and NAD+ linked to depression

Depression is now widely regarded as a common disabling disorder that affects negatively the social functioning of many all over the world. Depression is associated with diverse phenomena in the brain such as neuroinflammation, synaptic dysfunction, and cognitive deficit. Studies reported that depression occurs by various metabolic changes, leading to metabolic syndrome.

A scientific review was published summarizing recent evidences that sirtuins are involved in depressive disorder and that sirtuin activation may improve the depressive symptoms associated with pathological phenomenon in metabolic stress condition. Sirtuins are NAD+-dependent class III histone deacetylases, known to regulate diverse biological mechanisms such as longevity, genomic stability, and inflammation. Several studies indicate that NAD+ boosting induces sirtuin activity.

As society ages, people suffer from metabolic syndrome through diabetes, obesity, and cardiovascular disease and subsequently suffer from depression by metabolic changes. The researchers identified and found evidence of four possible mechanisms of sirtuin involvement:

(1) situins may control the inflammatory response in depression

(2) sirtuins might regulate the insufficient level of neurotransmitters in depression

(3) sirtuins may improve the synaptic dysfunction caused by depression

(4) sirtuis may alleviate the cognitive decline caused by depression.

Overall the researchers propose further studies regarding sirtuin’s role, suggesting that manipulation of sirtuins may be a therapeutic strategy for depression.

Although not specifically mentioned in the study  for example nicotinamide riboside, honokiol and fisetin are know sirtuin activators.

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