One of the questions when using supplementation is the dosing. How much to take? What to expect?
On this blog I have written and published several articles about research with Nicotinamide Riboside (NR). In part of these studies NR was administered orally and human doses for supplementation could be calculated. On this page you can find a summary of these outcomes. The calculated dosing can be found in the last column. For the calculation FDA guidelines were used.
It can be seen that for therapeutic applications the researchers typically have chosen for high dosing which resulted in positive effects. These doses are clearly higher that the recommended doses written on the packages of sold supplements which is typically 250mg / day and also higher than the estimated maximum values from the safety assessment. It should be noted that this safety level is somewhat conservative (please read the article). Nevertheless dosing at these high levels should likely only be done under medical supervision.
Testing by Chromadex has however shown that NAD+ is clearly raised already at lower levels of supplementation (100 mg, 300 mg and 1 gram doses of NR) suggesting that positive effects should also occur at lower levels. Unfortunately the researchers in these studies did not repeat the tests at lower dosing levels leaving it somewhat open what the minimum effective dose is. Personally I have used NR daily with dosing ranging from 250-500mg and have settled at a level of 375mg / day with good perceived benefits for my health, mental and physical condition. As people come in all forms and sizes a good range for experimentation in my view is from 125mg-500mg.
Here the overview, will update this regularly:
Application – Outcome – Animal Model & Dose – Human Equivalent Dose – Dose for 70kg (154lbs) person
Safety Test Safe Rat-300mg/kg/day 48mg/kg/day 288mg/day
Metabolism Positive Mice-30mg/kg/day 2.4mg/kg / day 170mg/day
Alzheimer’s Positive Mice-250mg/kg/day 20mg/kg/day 1.1g/day
Lifespan Positive Mice-400mg/kg/day 32mg/kg/day 2.1g/day
Liver injury Positive Mice-500mg/kg/day 41mg/kg/day 2.8g/day
Liver cancer Positive Mice-500mg/kg/day 41mg/kg/day 2.8g/day
NAFLD Positive Mice-500mg/kg/day 41mg/kg/day 2.8g/day
Diabetes Positive Mice-3g/kg/day 240mg/kg / day 17g/day