In June this year I published an article about the protective abilities of fisetin supplementation to protect the liver from damage caused by binge alcohol consumption, this month a new study was released reporting similar observations. A team from the University of North Carolina at Greensboro, Kannapolis set out to analyse whether dietary supplementation with fisetin exerts beneficial effect on alcohol-induced liver injury.
Mice were pair-fed with the control or ethanol (EtOH) diet for 4 weeks with or without fisetin supplementation at 10 mg/kg/d. In addition the researchers explored the potential molecular mechanisms through which the protective effect of fisetin may work.
The results showed clear benefits of the fisetin supplementation. In more detail it was observed that supplementation protects against alcohol-induced oxidative stress, hepatic apoptotic cell death and lipid accumulation. The authors concluded that next to the antioxidant ability, down-regulation of NOX4 and activation of ALDH (aldehyde dehydrogenase) contributes to the inhibitory effect on alcohol-induced oxidative stress. Prevention of apoptosis by fisetin was concluded to be the result from the suppression of Fas cell death signaling pathway. The up-regulation of hepatic enzymes likely causes the beneficial effect of fisetin on alcoholic fatty liver. In summary the protection is achieved by accelerating alcohol clearance and inhibition of oxidative stress.
Compared to the study about protective abilities of fisetin supplementation to protect the liver from damage caused by binge alcohol consumption not exactly the same parameters were evaluated but both studies observed that alcohol produced a significant increase in the oxidative stress markers, disturbed and induced histological changes in liver tissue and that fisetin supplementation reduced these alterations in liver function and histological changes and improved antioxidant defence.
The dosing used in this study was also 10mg/Kg/day. Using FDA specified guidelines we can calculate the Human Equivalent Dose (HED) for the diet given to the mice which results in approx. 0,8mg/kg. Or approximately 60mg daily fisetin dose for a person weighing 70kg. Typical supplements on the market have serving sizes of 100mg.
With now two studies indicating that fisetin has a therapeutic potential for treating and preventing ALD its case strenghtens. While the author discourages excessive alcohol use these outcomes do suggest that fisetin supplementation may be a sensible strategy to protect the liver from drinking alcohol.
You can find the new study here.