Charles Brenner, PhD who discovered Nicotinamide Riboside over a decade ago and described that in this paper in 2004 has a back and forth discussion about NR with the Nicotinamide Riboside [Curated] user group at LongeCity.org. The discussion runs into details but for those that have specific questions it may be worth to listen as many topics pass between the interviewer and Charles Brenner.
The trigger of the discussion appears to be the recently released papers about NR metabolism (I will blog about that a bit later). Some of the main things I picked up while listening:
- Twice a day dosing is sufficient, the bodies natural rhythm (circadian cycles peak twice a day inline with food consumption) fits to morning and evening dosing. Charles Brenner takes it in morning and just before dinner. But doesn’t specifically say anything about dosing amounts.
- Charles Brenner estimates there are 200k NR daily users globally, mostly 250mg / day
- Says you need to drink 100k’s of glasses of milk to match supplement dosing. Inline with this study.
- Sees NAD impacting various conditions e.g. obesity, diabetes due to its central place in cell bio energetics, dna repair, ROS, steriod synthesis etc
- Stresses that NAD keeps sirtuins active, in particular SIRT1 and helps our epigenetic profile and DNA machinery. See also this recent article about compounds that boost SIRT1
- Explains that NR supplementation leads to 2 waves of improved metabolism: first wave boosts NAD via NR pathway, second wave is nicotinamide released from sirtuins. Believes that the gradual, slow release of nicotinamide in this secondary wave helps NAD metabolism versus supplementation with high dose nicotinamide that testing shows bring no improvement in sirtuin activity.
- People with metabolic related diseases likely benefit more directly from NR supplementation than healthy people
- NR is easier converted to NAD than other pre-cursers, hints that is the reason that in injury and other damage situations some cells induce NRK2 e.g. in the heart to replenish NAD (NRK is an enzyme needed for NR processing into NAD)
- NR versus NMN. While NMN demonstrates similar benefits e.g. stimulates metabolism. NMN however cannot enter the cell and therefore will be converted to NR first to enter the cell upon which it is again converted to NMN in the cell. Indicating there is no benefit to direct NMN supplementation.
Here the interview (direct link to youtube here):