Alzheimer’s disease

Supplements reported to provide health benefits: Fisetin, Honokiol, Pterostilbene, Nicotinamide Riboside

This page of the site aims to provide news about research developments into the antioxidant, anti-inflammatory, anti-amyloidogenic, neuroprotective, and cognition-enhancing effects of a variety of supplements and nutraceuticals including fisetin, pterostilbene, honokiol etc  and their potential specifically for Alzheimer’s disease prevention and treatment.

There is optimism that therapeutic use of these compounds might lead to a safe strategy to delay the onset of Alzheimer’s disease or slow down its progression. These nature based compounds have typically good safety profiles and very affordable price and availability as most of them can be found in health stores. With a steady pace of research ongoing and with more results becoming available the compounds and supplements listed will likely evolve going forward.

Of all the people who have Alzheimer’s disease, about 5 percent develop symptoms before age 65. Early-onset Alzheimer’s has been known to develop between ages 30 and 40, but that’s very uncommon. It seems likely however that the damage to the brain starts a decade or more before memory and other cognitive problems appear. During this preclinical stage of Alzheimer’s disease, people seem to be symptom-free, but toxic changes are taking place in the brain. The damage initially appears to take place in the hippocampus, the part of the brain essential in forming memories. As more neurons die, additional parts of the brain are affected. AD is therefore a progressive neurodegenerative disorder with irreversible impairment of intellect, alteration of memory, language and behavioral problems finally, leading to death.

The disease is most prominently characterized by the accumulation of amyloid plaques and neurofibrillary tangles. Neuroinflammation and oxidative stresses are also hallmarks of Alzheimer disease. For this reason, an adequate antioxidant strategy may improve the treatment of neurodegenerative diseases and dementia. Several studies support the neuroprotective abilities of polyphenolic compounds resulting in neuronal protection against injury induced by neurotoxins, ability to suppress neuroinflammation and the potential to promote memory, learning and cognitive functions.

There is also mounting evidence that maintaining cell metabolism may stall progression of AD. The activation of NAD+ expression is linked with a decrease in beta-amyloid (Aβ) toxicity. This makes compounds like nicotinamide riboside which increase the NAD+ pool attractive as candidates to ward off AD symptoms as we age.

Finally a nutritious diet, physical activity, social engagement, and mentally stimulating pursuits have all been associated with helping people stay healthy as they age.