Supplements reported to provide health benefits: Fisetin, Quercetin, Pterostilbene, Nicotinamide Riboside

This page of the site aims to provide news about research developments into anti-obesity effects of a variety of supplements and nutraceuticals like fisetin, pterostilbene, honokiol etc  and their potential specifically for helping prevent and treat obesity.

Obesity means having too much body fat. It is different from being overweight, which means weighing too much. The weight may come from muscle, bone, fat, and/or body water. Both terms mean that a person’s weight is greater than what’s considered healthy for his or her height.

Obesity occurs over time when you eat more calories than you use. The balance between calories-in and calories-out differs for each person. Factors that might affect your weight include your genetic makeup, overeating, eating high-fat foods, and not being physically active.

Being obese increases your risk of diabetes, heart disease, stroke, arthritis, and some cancers. If you are obese, losing even 5 to 10 percent of your weight can delay or prevent some of these diseases. For example, that means losing 10 to 20 pounds if you weigh 200 pounds.

With the many recent advances in the biomedical world, knowledge of the physiological aspects of almost all the tissues and organs of the human body have improved and changed. One of the topics often discussed is the question of obesity and its effect on the metabolic changes in the human body. The original classical understanding of the role of adipose (fat) tissue was that it is an energy storage organ. We now know that it is an endocrine organ, producing adipokines like leptin, adiponectin, visfatin, resistin, apelin, etc, which modulate metabolic processes in the body.  The expansion of adipose (fat) tissue produces an increased volume of these bioactive substances, in general known as adipocytokines or adipokines, which trigger chronic low-grade inflammation and interact with a range of processes in many different organs. Although the precise mechanisms are still unclear, dysregulated production or secretion of these adipokines caused by excess adipose tissue and adipose tissue dysfunction can contribute to the development of obesity-related metabolic diseases. For example the inflammation originating from the adipose tissue is considered to be one of the main driving forces for the development of insulin resistance and type 2 diabetes in obese individuals.

There is however increasing research that therapeutic use of polyphenic compounds and nutraceuticals might lead to a safe strategy to help control obesity and slow some of the health risks it causes. These nature based compounds have typically good safety profiles and very affordable price and availability as most of them can be found in health stores. With a steady pace of research ongoing and with more results becoming available hopefully effective compounds and supplements will be identified.

Finally a nutritious diet and physical activity are proven positive influences on treating and overcoming obesity and should be the basis of any treatment regime. Results indicate that the best way to lose weight is slowly. A weight loss of 1 to 2 pounds a week is do-able, safe, and helps keep off the weight. It also will give you the time to make new, healthy lifestyle changes.