More proof coffee may make you old, inhibits SIRT1,2 & 3
Earlier this year I wrote this article about a compound that was isolated from coffee extract. It is called javamide-II and is a
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SIRT3
Boosting NAD+ delays stem cell senescence and reprograms aged somatic cells
Stem cell therapy research is becoming increasingly popular with results to show. In clinical trials, the use of mesenchymal stem cells
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Research shows sirtuins regulated by NAD+ concentration, no direct NAD/NADH ratio influence
Sirtuins are NAD-dependent deacetylases that are highly conserved from bacteria to human. SIR2 was originally shown to extend lifespan in
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Quercetin & Apegenin slow down the escalating NAD+ consumption by CD38 as we age
The last months have seen a couple publications highlighting a link between the expression and activity of the NADase CD38
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Nicotinamide Riboside reverses fatty liver disease in mice
Nonalcoholic fatty liver disease (NAFLD) is a term used to describe the accumulation of fat in the liver of people
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NIH study finds that Nicotinamide Riboside activates SIRT3 which reduces obesity-related inflammation
Scientists at the National Institutes of Health carried out a study to find potential molecular targets for reducing obesity-related inflammation.
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Honokiol compound could help to prevent heart failure
An in vivo study in mice showing that Honokiol can protect the heart from hypertrophy. Hyperthrophy is a thickening of
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Honokiol increases SIRT3 levels and stops cardiac hypertrophy in mice
In an expansive study, researchers found that Honokiol increases levels of SIRT3. This appears to be the first ever report
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Nicotinamide Riboside (NR) successfully prevented short- and long-term hearing loss
In research published in the journal Cell Metabolism, nicotinamide riboside (NR) successfully prevented short- and long-term hearing loss in mice
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