Research shows sirtuins regulated by NAD+ concentration, no direct NAD/NADH ratio influence
Sirtuins are NAD-dependent deacetylases that are highly conserved from bacteria to human. SIR2 was originally shown to extend lifespan in
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SIRT6
Human study finds high-fat food decreases SIRT1 & 6 and increases SIRT4 levels, establishes link to disease and obesity
Typical western diets consist of poor food choices over a lifetime that can contribute to diet-induced obesity, systemic inflammation and
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Sirt6 activation potentially beneficial for prevention and treatment of osteoarthritis
Osteoarthritis (OA) is an age-related degenerative disease of the joint which is characterized by progressive degradation of cartilage along with
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