Charles Brenner, discoverer of NR, speaks with a Nicotinamide Riboside user group
Charles Brenner, PhD who discovered Nicotinamide Riboside over a decade ago and described that in this paper in 2004 has
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sirtuins
More proof coffee may make you old, inhibits SIRT1,2 & 3
Earlier this year I wrote this article about a compound that was isolated from coffee extract. It is called javamide-II and is a
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Research shows sirtuins regulated by NAD+ concentration, no direct NAD/NADH ratio influence
Sirtuins are NAD-dependent deacetylases that are highly conserved from bacteria to human. SIR2 was originally shown to extend lifespan in
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Study finds boosting SIRT1 may prevent and treat Osteoporosis
Earlier in the year this study linked a decline in mitochondrial function to bone loss and osteoporosis. In this just released
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Quercetin & Apegenin slow down the escalating NAD+ consumption by CD38 as we age
The last months have seen a couple publications highlighting a link between the expression and activity of the NADase CD38
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Human study finds high-fat food decreases SIRT1 & 6 and increases SIRT4 levels, establishes link to disease and obesity
Typical western diets consist of poor food choices over a lifetime that can contribute to diet-induced obesity, systemic inflammation and
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Alcohol may injure the liver, other organs by reducing NAD+ pool required for sirtuin activity
Using existing research and experimental results a scientist pieces a mechanism together how alcohol injures the liver and other organs
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Nicotinamide Riboside reverses fatty liver disease in mice
Nonalcoholic fatty liver disease (NAFLD) is a term used to describe the accumulation of fat in the liver of people
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Sirt6 activation potentially beneficial for prevention and treatment of osteoarthritis
Osteoarthritis (OA) is an age-related degenerative disease of the joint which is characterized by progressive degradation of cartilage along with
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Sirtuins and NAD+ linked to depression
Depression is now widely regarded as a common disabling disorder that affects negatively the social functioning of many all over
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