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Nicotinamide Riboside 

Charles Brenner, discoverer of NR, speaks with a Nicotinamide Riboside user group

October 24, 2016November 15, 2016 Timeless_One 7 Comments Charles Brenner, nicotinamide riboside, NR, SIRT1, sirtuins

Charles Brenner, PhD who discovered Nicotinamide Riboside over a decade ago and described that in this paper in 2004 has

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killercoffee2
General 

More proof coffee may make you old, inhibits SIRT1,2 & 3

October 15, 2016October 16, 2016 Timeless_One 9 Comments anti-aging, cancer, coffee, longevity, SIRT1, SIRT2, SIRT3, sirtuins

Earlier this year I wrote this article about a compound that was isolated from coffee extract. It is called javamide-II and is a

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NADNADHSIRT
General Nicotinamide Riboside Quercetin 

Research shows sirtuins regulated by NAD+ concentration, no direct NAD/NADH ratio influence

July 9, 2016July 10, 2016 Timeless_One 0 Comment NAD+, NADH, nicotinamide riboside, NR, SIRT1, SIRT3, SIRT6, sirtuins

Sirtuins are NAD-dependent deacetylases that are highly conserved from bacteria to human. SIR2 was originally shown to extend lifespan in

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boneformation
bone health Nicotinamide Riboside Quercetin 

Study finds boosting SIRT1 may prevent and treat Osteoporosis

July 6, 2016July 6, 2016 Timeless_One 0 Comment NAD+, nicotinamide riboside, NR, osteoporosis, quercetin, SIRT1, sirtuins

Earlier in the year this study linked a decline in mitochondrial function to bone loss and osteoporosis. In this just released

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CD38
Quercetin 

Quercetin & Apegenin slow down the escalating NAD+ consumption by CD38 as we age

June 29, 2016February 10, 2019 Timeless_One 0 Comment apegenin, CD38, mitochondria, NAD+, quercetin, SIRT1, SIRT3, sirtuins

The last months have seen a couple publications highlighting a link between the expression and activity of the NADase CD38

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highfatdiet
Nicotinamide Riboside obesity Pterostilbene 

Human study finds high-fat food decreases SIRT1 & 6 and increases SIRT4 levels, establishes link to disease and obesity

May 23, 2016November 7, 2016 Timeless_One 0 Comment nicotinamide riboside, obesity, Pterostilbene, SIRT1, SIRT4, SIRT6, sirtuins, weight management

Typical western diets consist of poor food choices over a lifetime that can contribute to diet-induced obesity, systemic inflammation and

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liver
Nicotinamide Riboside 

Alcohol may injure the liver, other organs by reducing NAD+ pool required for sirtuin activity

May 2, 2016May 28, 2016 Timeless_One 0 Comment liver disease, NAD+, nicotinamide riboside, sirtuins

Using existing research and experimental results a scientist pieces a mechanism together how alcohol injures the liver and other organs

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NFALD
Nicotinamide Riboside 

Nicotinamide Riboside reverses fatty liver disease in mice

April 28, 2016November 7, 2016 Timeless_One 0 Comment liver disease, NAFLD, nicotinamide riboside, nonalcoholic fatty liver disease, SIRT1, SIRT3, sirtuins

Nonalcoholic fatty liver disease (NAFLD) is a term used to describe the accumulation of fat in the liver of people

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SIRT6OA
bone health Nicotinamide Riboside osteoarthritis 

Sirt6 activation potentially beneficial for prevention and treatment of osteoarthritis

April 23, 2016July 6, 2016 Timeless_One 0 Comment aging, nicotinamide riboside, osteoarthritis, SIRT6, sirtuins

Osteoarthritis (OA) is an age-related degenerative disease of the joint which is characterized by progressive degradation of cartilage along with

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sirtuinsdepression
Alzheimer's disease depression Nicotinamide Riboside 

Sirtuins and NAD+ linked to depression

April 19, 2016February 10, 2019 Timeless_One 0 Comment depression, fisetin, Honokiol, NAD+, neuroprotection, nicotinamide riboside, SIRTS, sirtuins

Depression is now widely regarded as a common disabling disorder that affects negatively the social functioning of many all over

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Compounds & Supplements

  • Nicotinamide Riboside
  • Pterostilbene
  • Honokiol
  • Quercetin
  • Fisetin
  • Anthocyanins

Popular posts & pages

  • Personal experiences: My hair regrowth and why I think an NR experiment may
  • Personal Experiences (updated 26th of March 17)
  • Nicotinamde Riboside Dosing Overview (updated 11th of November 2016)
  • Study shows mice on NMN drinking water stay young, makes questionable…
  • Star research team maps NR and NMN conversion path to cellular NAD+
  • SIRT1 boosting with nutraceuticals, study reveals most effective compounds…
  • Nicotinamide Riboside
  • 3 + years use of Niagen (nicotinamide riboside) and plant supplements
  • New safety assessment of nicotinamide riboside published
  • Longevity news and studies

Health challenges

  • Alzheimer's disease
  • Advanced Glycation End products
  • Obesity

Miscellaneous articles

  • End of  2018, that hair is still going strong

    End of 2018, that hair is still going strong

    December 23, 2018
  • 3 + years use of Niagen (nicotinamide riboside) and plant supplements

    3 + years use of Niagen (nicotinamide riboside) and plant supplements

    May 19, 2018
  • Personal experiences: dosing & timing experiment

    Personal experiences: dosing & timing experiment

    November 25, 2017
  • Niagen sales grow on Amazon.com to 7.9M USD/Year (September estimation) + Best sellers & Best prices.

    Niagen sales grow on Amazon.com to 7.9M USD/Year (September estimation) + Best sellers & Best prices.

    October 1, 2017
  • Niagen sales on Amazon.com: 5.6M USD/Year (estimation). List of best sellers & best prices.

    Niagen sales on Amazon.com: 5.6M USD/Year (estimation). List of best sellers & best prices.

    July 29, 2017
  • Personal experiences: Summer is here

    Personal experiences: Summer is here

    July 18, 2017
  • Richest man in Asia invests in Chromadex (Niagen), will own 20% of company

    Richest man in Asia invests in Chromadex (Niagen), will own 20% of company

    April 28, 2017
  • Personal experiences: became 47 this week, 2 years of nutraceuticals, can I stay in my 30s forever?

    Personal experiences: became 47 this week, 2 years of nutraceuticals, can I stay in my 30s forever?

    March 26, 2017
  • Elysium Health appears  under increasing criticism, now sued for not paying bills

    Elysium Health appears under increasing criticism, now sued for not paying bills

    January 8, 2017
  • Personal experiences: My hair regrowth and why I think an NR experiment may be the reason

    Personal experiences: My hair regrowth and why I think an NR experiment may be the reason

    November 22, 2016
  • Study shows mice on NMN drinking water stay young, makes questionable dosing conclusion

    Study shows mice on NMN drinking water stay young, makes questionable dosing conclusion

    November 5, 2016
  • SIRT1 boosting with nutraceuticals, study reveals most effective compounds and combinations

    SIRT1 boosting with nutraceuticals, study reveals most effective compounds and combinations

    October 21, 2016
  • More proof coffee may make you old, inhibits SIRT1,2 & 3

    More proof coffee may make you old, inhibits SIRT1,2 & 3

    October 15, 2016
  • personal experiences update – facial structure picture comparison after 1.5 year use

    personal experiences update – facial structure picture comparison after 1.5 year use

    September 18, 2016
  • Pomegranates, Urolithin A, Mitophagy, Mitochondrial cleanup –  (part 1)

    Pomegranates, Urolithin A, Mitophagy, Mitochondrial cleanup – (part 1)

    July 20, 2016
  • Research shows sirtuins regulated by NAD+ concentration, no direct NAD/NADH ratio influence

    Research shows sirtuins regulated by NAD+ concentration, no direct NAD/NADH ratio influence

    July 9, 2016
  • Why do flavonoid topoisomerase II poisons preferentially kill cancer cells?

    Why do flavonoid topoisomerase II poisons preferentially kill cancer cells?

    July 5, 2016
  • Man with severe dementia significantly recovers after treatment with natural enzyme

    Man with severe dementia significantly recovers after treatment with natural enzyme

    June 10, 2016
  • Study provides evidence that supplements may help prevent cancer in your dog

    Study provides evidence that supplements may help prevent cancer in your dog

    May 30, 2016
  • Dark chocolate is neuroprotective in rats prone to Alzheimer’s Disease

    Dark chocolate is neuroprotective in rats prone to Alzheimer’s Disease

    May 4, 2016
  • Coffee makes you old? Study indicates that coffee extract inhibits SIRT1/2

    Coffee makes you old? Study indicates that coffee extract inhibits SIRT1/2

    April 6, 2016
  • The epigenetic role of vitamin C in health and disease

    The epigenetic role of vitamin C in health and disease

    April 5, 2016
  • This is how men look at the age of 46 and 40

    This is how men look at the age of 46 and 40

    April 2, 2016
  • 37.2 trillion cells and other incredible cell statistics about the human body

    37.2 trillion cells and other incredible cell statistics about the human body

    March 29, 2016
  • Most popular Amino Acids – search statistics

    Most popular Amino Acids – search statistics

    March 24, 2016
  • Impressive success in regeneration of eye lenses with stem cells

    Impressive success in regeneration of eye lenses with stem cells

    March 10, 2016
  • Fine-Tuning and regulation of Cellular Energy Increases Longevity

    Fine-Tuning and regulation of Cellular Energy Increases Longevity

    March 8, 2016
  • Short-lived killifish reveals connection between gene expression and longevity

    Short-lived killifish reveals connection between gene expression and longevity

    March 7, 2016
  • Mitochondrial energy decline cause for failing hearts

    Mitochondrial energy decline cause for failing hearts

    February 28, 2016
  • Scientists find decline in mitochondrial Complex II activity in senescent human skin cells as we age

    Scientists find decline in mitochondrial Complex II activity in senescent human skin cells as we age

    February 20, 2016
  • Scientists have identified 1500 genes connected to how we age

    Scientists have identified 1500 genes connected to how we age

    October 25, 2015
  • Parkinson’s patients ‘walk and talk again’ when taking cancer drug

    Parkinson’s patients ‘walk and talk again’ when taking cancer drug

    October 19, 2015
  • Antioxidants linked to spread of skincancer

    Antioxidants linked to spread of skincancer

    October 17, 2015
  • Why elephants rarely get cancer: Potential mechanism identified that may be key to cancer resistance

    Why elephants rarely get cancer: Potential mechanism identified that may be key to cancer resistance

    October 12, 2015

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