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Nicotinamide Riboside

Charles Brenner, discoverer of NR, speaks with a Nicotinamide Riboside user group

October 24, 2016November 15, 2016 Timeless_One 7 Comments Charles Brenner, nicotinamide riboside, NR, SIRT1, sirtuins

Charles Brenner, PhD who discovered Nicotinamide Riboside over a decade ago and described that in this paper in 2004 has

General

More proof coffee may make you old, inhibits SIRT1,2 & 3

October 15, 2016October 16, 2016 Timeless_One 6 Comments anti-aging, cancer, coffee, longevity, SIRT1, SIRT2, SIRT3, sirtuins

Earlier this year I wrote this article about a compound that was isolated from coffee extract. It is called javamide-II and is a

General Nicotinamide Riboside Quercetin

Research shows sirtuins regulated by NAD+ concentration, no direct NAD/NADH ratio influence

July 9, 2016July 10, 2016 Timeless_One 0 Comment NAD+, NADH, nicotinamide riboside, NR, SIRT1, SIRT3, SIRT6, sirtuins

Sirtuins are NAD-dependent deacetylases that are highly conserved from bacteria to human. SIR2 was originally shown to extend lifespan in

bone health Nicotinamide Riboside Quercetin

Study finds boosting SIRT1 may prevent and treat Osteoporosis

July 6, 2016July 6, 2016 Timeless_One 0 Comment NAD+, nicotinamide riboside, NR, osteoporosis, quercetin, SIRT1, sirtuins

Earlier in the year this study linked a decline in mitochondrial function to bone loss and osteoporosis. In this just released

Quercetin

Quercetin & Apegenin slow down the escalating NAD+ consumption by CD38 as we age

June 29, 2016November 15, 2016 Timeless_One 0 Comment apegenin, CD38, mitochondria, NAD+, quercetin, SIRT1, SIRT3, sirtuins

The last months have seen a couple publications highlighting a link between the expression and activity of the NADase CD38

Nicotinamide Riboside obesity Pterostilbene

Human study finds high-fat food decreases SIRT1 & 6 and increases SIRT4 levels, establishes link to disease and obesity

May 23, 2016November 7, 2016 Timeless_One 0 Comment nicotinamide riboside, obesity, Pterostilbene, SIRT1, SIRT4, SIRT6, sirtuins, weight management

Typical western diets consist of poor food choices over a lifetime that can contribute to diet-induced obesity, systemic inflammation and

Nicotinamide Riboside

Alcohol may injure the liver, other organs by reducing NAD+ pool required for sirtuin activity

May 2, 2016May 28, 2016 Timeless_One 0 Comment liver disease, NAD+, nicotinamide riboside, sirtuins

Using existing research and experimental results a scientist pieces a mechanism together how alcohol injures the liver and other organs

Nicotinamide Riboside

Nicotinamide Riboside reverses fatty liver disease in mice

April 28, 2016November 7, 2016 Timeless_One 0 Comment liver disease, NAFLD, nicotinamide riboside, nonalcoholic fatty liver disease, SIRT1, SIRT3, sirtuins

Nonalcoholic fatty liver disease (NAFLD) is a term used to describe the accumulation of fat in the liver of people

bone health Nicotinamide Riboside osteoarthritis

Sirt6 activation potentially beneficial for prevention and treatment of osteoarthritis

April 23, 2016July 6, 2016 Timeless_One 0 Comment aging, nicotinamide riboside, osteoarthritis, SIRT6, sirtuins

Osteoarthritis (OA) is an age-related degenerative disease of the joint which is characterized by progressive degradation of cartilage along with

Alzheimer's disease depression Nicotinamide Riboside

Sirtuins and NAD+ linked to depression

April 19, 2016November 7, 2016 Timeless_One 0 Comment depression, fisetin, Honokiol, NAD+, neuroprotection, nicotinamide riboside, SIRTS, sirtuins

Depression is now widely regarded as a common disabling disorder that affects negatively the social functioning of many all over

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